HMM Summary Page: TIGR03037

Function3-hydroxyanthranilate 3,4-dioxygenase
Gene SymbolnbaC
Trusted Cutoff145.95
Domain Trusted Cutoff145.95
Noise Cutoff57.60
Domain Noise Cutoff57.60
Isology Typeequivalog
EC Number1.13.11.6
HMM Length159
AuthorHaft DH
Entry DateAug 8 2006 1:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, from both bacteria and eukaryotes, are the enzyme 3-hydroxyanthranilate 3,4-dioxygenase. This enzyme acts on the tryptophan metabolite 3-hydroxyanthranilate and produces 2-amino-3-carboxymuconate semialdehyde, which can rearrange spontaneously to quinolinic acid and feed into nicotinamide biosynthesis, or undergo further enzymatic degradation.
ReferencesRN [1] RM PMID: 12620844 RT Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7. RA Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC RL Appl Environ Microbiol. 2003 Mar;69(3):1564-72. DR HAMAP; MF_00825; 15 of 15