HMM Summary Page: TIGR03036

Functiontryptophan 2,3-dioxygenase
Gene SymbolkynA
Trusted Cutoff390.70
Domain Trusted Cutoff390.70
Noise Cutoff118.90
Domain Noise Cutoff118.90
Isology Typeequivalog
EC Number1.13.11.11
HMM Length264
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0004833: tryptophan 2,3-dioxygenase activity molecular_function
GO:0019441: tryptophan catabolic process to kynurenine biological_process
AuthorHaft DH
Entry DateAug 7 2006 1:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine.
ReferencesDR PFAM; PF03301; Tryptophan 2,3-dioxygenase RN [1] RM PMID: 14592712 RT Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. RA Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A RL FEMS Microbiol Lett. 2003 Oct 24;227(2):219-27. RN [2] RM PMID: 15066027 RT The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. RA Matthijs S, Baysse C, Koedam N, Tehrani KA, Verheyden L, Budzikiewicz H, Schafer M, Hoorelbeke B, Meyer JM, De Greve H, Cornelis P RL Mol Microbiol. 2004 Apr;52(2):371-84.
Genome PropertyGenProp0659: tryptophan degradation to anthranilate (HMM)