HMM Summary Page: TIGR03035

Gene SymbolkynB
Trusted Cutoff223.05
Domain Trusted Cutoff223.05
Noise Cutoff179.75
Domain Noise Cutoff179.75
Isology Typeequivalog
EC Number3.5.1.9
HMM Length206
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0004061: arylformamidase activity molecular_function
GO:0019441: tryptophan catabolic process to kynurenine biological_process
AuthorHaft DH
Entry DateAug 7 2006 12:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentOne of several pathways of tryptophan degradation is as follows: tryptophan 2,3-dioxygenase ( uses 02 to convert Trp to L-formylkynurenine. Arylformamidase ( hydrolyzes the product to L-kynurenine and formate. Kynureninase ( hydrolyzes L-kynurenine to anthranilate plus alanine. Members of the seed alignment for this model are bacterial predicted metal-dependent hydrolases. All are supported as arylformamidase ( by an operon structure in which kynureninase and/or tryptophan 2,3-dioxygenase genes are adjacent. The members from Bacillus cereus, Pseudomonas aeruginosa and Ralstonia metallidurans were characterized. An example from Pseudomonas fluorescens is given the gene symbol qbsH instead of kynB because of its role in quinolobactin biosynthesis, which begins with tryptophan. All members of this family should be arylformamidase (
ReferencesRN [1] RM PMID: 14592712 RT Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. RA Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A RL FEMS Microbiol Lett. 2003 Oct 24;227(2):219-27. RN [2] RM PMID: 15066027 RT The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. RA Matthijs S, Baysse C, Koedam N, Tehrani KA, Verheyden L, Budzikiewicz H, Schafer M, Hoorelbeke B, Meyer JM, De Greve H, Cornelis P RL Mol Microbiol. 2004 Apr;52(2):371-84.
Genome PropertyGenProp0659: tryptophan degradation to anthranilate (HMM)