HMM Summary Page: TIGR03026

Functionnucleotide sugar dehydrogenase
Trusted Cutoff189.80
Domain Trusted Cutoff189.80
Noise Cutoff105.10
Domain Noise Cutoff105.10
Isology Typesubfamily
HMM Length413
AuthorSelengut J
Entry DateJul 30 2006 10:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentEnzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase ( [1], GDP-mannose 6-dehydrogenase ( [2], UDP-N-acetylglucosamine 6-dehydrogenase ( [3], UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase [4] and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [5]. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, PF03721, PF00984, and PF03720 for the N-terminal, central, and C-terminal regions respectively.
ReferencesRN [1] RM PMID: 10376820 RT Assay for UDPglucose 6-dehydrogenase in phosphate-starved cells: gene tuaD of Bacillus subtilis 168 encodes the UDPglucose 6-dehydrogenase involved in teichuronic acid synthesis. RA Pagni M, Lazarevic V, Soldo B, Karamata D RL Microbiology. 1999 May;145 ( Pt 5):1049-53. RN [2] RM PMID: 8606150 RT Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii. RA Campos M, Martinez-Salazar JM, Lloret L, Moreno S, Nunez C, Espin G, Soberon-Chavez G RL J Bacteriol. 1996 Apr;178(7):1793-9. RN [3] RM PMID: 15226302 RT Biochemical characterization of WbpA, a UDP-N-acetyl-D-glucosamine 6-dehydrogenase involved in O-antigen biosynthesis in Pseudomonas aeruginosa PAO1. RA Miller WL, Wenzel CQ, Daniels C, Larocque S, Brisson JR, Lam JS RL J Biol Chem. 2004 Sep 3;279(36):37551-8. Epub 2004 Jun 28. RN [4] RM PMID: 10931835 RT WbpO, a UDP-N-acetyl-D-galactosamine dehydrogenase from Pseudomonas aeruginosa serotype O6. RA Zhao X, Creuzenet C, Belanger M, Egbosimba E, Li J, Lam JS RL J Biol Chem. 2000 Oct 27;275(43):33252-9. RN [5] RM PMID: 2166030 RT Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis. RA Meier-Dieter U, Starman R, Barr K, Mayer H, Rick PD RL J Biol Chem. 1990 Aug 15;265(23):13490-7.
Genome PropertyGenProp0969: biosynthesis of UDP-N-acetyl-D-mannosaminuronic acid (UDP-ManNAcA) (HMM-CLUST)