| Accession | TIGR03011 |
| Name | sulf_tusB_dsrH |
| Function | sulfur relay protein TusB/DsrH |
| Gene Symbol | dsrH |
| Trusted Cutoff | 49.20 |
| Domain Trusted Cutoff | 49.20 |
| Noise Cutoff | 29.40 |
| Domain Noise Cutoff | 29.40 |
| Isology Type | equivalog_domain |
| EC Number | 2.8.-.- |
| HMM Length | 95 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA and rRNA base modification |
| Gene Ontology Term | GO:0002098: tRNA wobble uridine modification biological_process |
| | GO:0016782: transferase activity, transferring sulfur-containing groups molecular_function |
| Author | Haft DH |
| Entry Date | Jul 21 2006 4:12PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulfur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulfide moiety, delivered by the cysteine desulfurase IscS to TusA, then to TusBCD. The activated sulfur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln. The sulfur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulfur bacteria, such as Chromatium vinosum. In these organisms, it seems the primary purpose is related to sulfur flux, such as oxidation from sulfide to molecular sulfur to sulfate. |
| References | RN [1]
RM PMID: 16387657
RT Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions.
RA Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T
RL Mol Cell. 2006 Jan 6;21(1):97-108.
RN [2]
RM PMID: 9695921
RT Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.
RA Pott AS, Dahl C
RL Microbiology. 1998 Jul;144 ( Pt 7):1881-94.
DR HAMAP; MF_01564; 37 of 38 |
| Genome Property | GenProp0654: intracellular sulfur oxidation (HMM) |
