HMM Summary Page: TIGR03002

Functionlipopolysaccharide transport periplasmic protein LptA
Gene SymbollptA
Trusted Cutoff71.70
Domain Trusted Cutoff71.70
Noise Cutoff34.80
Domain Noise Cutoff34.80
Isology Typeequivalog
HMM Length142
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0001530: lipopolysaccharide binding molecular_function
GO:0015920: lipopolysaccharide transport biological_process
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorHaft DH
Entry DateJul 13 2006 4:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly.
ReferencesRN [1] RM PMID:17056748 RT Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli. RA Sperandeo P, Cescutti R, Villa R, Di Benedetto C, Candia D, Deho G, Polissi A RL J Bacteriol. 2007 Jan;189(1):244-53. RN [2] RM PMID: 16765569 RT Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus. RA Sperandeo P, Pozzi C, Deho G, Polissi A RL Res Microbiol. 2006 Feb 9
Genome PropertyGenProp1079: Lpt lipopolysaccharide export transenvelope protein complex (HMM)