| Accession | TIGR03002 |
| Name | outer_YhbN_LptA |
| Function | lipopolysaccharide transport periplasmic protein LptA |
| Gene Symbol | lptA |
| Trusted Cutoff | 71.70 |
| Domain Trusted Cutoff | 71.70 |
| Noise Cutoff | 34.80 |
| Domain Noise Cutoff | 34.80 |
| Isology Type | equivalog |
| HMM Length | 142 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0001530: lipopolysaccharide binding molecular_function |
| | GO:0015920: lipopolysaccharide transport biological_process |
| | GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| | GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component |
| Author | Haft DH |
| Entry Date | Jul 13 2006 4:54PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. |
| References | RN [1]
RM PMID:17056748
RT Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli.
RA Sperandeo P, Cescutti R, Villa R, Di Benedetto C, Candia D, Deho G, Polissi A
RL J Bacteriol. 2007 Jan;189(1):244-53.
RN [2]
RM PMID: 16765569
RT Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus.
RA Sperandeo P, Pozzi C, Deho G, Polissi A
RL Res Microbiol. 2006 Feb 9 |
| Genome Property | GenProp1079: Lpt lipopolysaccharide export transenvelope protein complex (HMM) |
