HMM Summary Page: TIGR02987

Functiontype II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family
Trusted Cutoff353.50
Domain Trusted Cutoff353.50
Noise Cutoff116.10
Domain Noise Cutoff116.10
Isology Typesubfamily_domain
EC Number2.1.1.72
HMM Length523
Mainrole CategoryDNA metabolism
Subrole CategoryRestriction/modification
AuthorHaft DH
Entry DateJun 28 2006 3:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the m6-adenine DNA methyltransferase protein, or domain of a fusion protein that also carries m5 cytosine methyltransferase activity, of type II restriction systems of the Alw26I/Eco31I/Esp3I family. A methyltransferase of this family is alway accompanied by a type II restriction endonuclease from the Alw26I/Eco31I/Esp3I family (TIGR02986) and by an adenine-specific modification methyltransferase. Members of this family are unusual in that regions of similarity to homologs outside this family are circularly permuted.
ReferencesRN [1] RM PMID: 12172806 RT Evolutionary relationship of Alw26I, Eco31I and Esp3I, restriction endonucleases that recognise overlapping sequences. RA Bitinaite J, Mitkaite G, Dauksaite V, Jakubauskas A, Timinskas A, Vaisvila R, Lubys A, Janulaitis A RL Mol Genet Genomics. 2002 Jul;267(5):664-72. Epub 2002 Jun 19.
Genome PropertyGenProp0650: type II restriction system, Alw26I/Eco31I/Esp3I family (HMM)