HMM Summary Page: TIGR02967

Functionguanine deaminase
Gene SymbolguaD
Trusted Cutoff375.40
Domain Trusted Cutoff375.40
Noise Cutoff285.30
Domain Noise Cutoff285.30
Isology Typeequivalog
EC Number3.5.4.3
HMM Length401
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryOther
Gene Ontology TermGO:0006147: guanine catabolic process biological_process
GO:0008892: guanine deaminase activity molecular_function
AuthorHaft DH
Entry DateJun 9 2006 10:36AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes guanine deaminase, which hydrolyzes guanine to xanthine and ammonia. Xanthine can then be converted to urate by xanthine dehydrogenase, and urate subsequently degraded. In some bacteria, the guanine deaminase gene is found near the xdhABC genes for xanthine dehydrogenase. Non-homologous forms of guanine deaminase also exist, as well as distantly related forms outside the scope of this model.
ReferencesDR URL; DR BRENDA; RN [1] RM PMID: 10913105 RT Identification, expression, and characterization of Escherichia coli guanine deaminase. RA Maynes JT, Yuan RG, Snyder FF RL J Bacteriol. 2000 Aug;182(16):4658-60.
Genome PropertyGenProp0698: xanthine catabolism to urate (HMM)