HMM Summary Page: TIGR02962

Functionhydroxyisourate hydrolase
Gene SymboluraH
Trusted Cutoff87.45
Domain Trusted Cutoff87.45
Noise Cutoff79.80
Domain Noise Cutoff79.80
Isology Typeequivalog
EC Number3.5.2.17
HMM Length113
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryOther
Gene Ontology TermGO:0019628: urate catabolic process biological_process
AuthorSelengut J, Haft DH
Entry DateJun 7 2006 2:46PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family, hydroxyisourate hydrolase, represent a distinct clade of transthyretin-related proteins. Bacterial members typically are encoded next to ureidoglycolate hydrolase and often near either xanthine dehydrogenase or xanthine/uracil permease genes and have been demonstrated to have hydroxyisourate hydrolase activity [1]. In eukaryotes, a clade separate from the transthyretins (a family of thyroid-hormone binding proteins) has also been shown to have HIU hydrolase activity in urate catabolizing organisms [2]. Transthyretin, then, would appear to be the recently diverged paralog of the more ancient HIUH family.
ReferencesRN [1] RM PMID: 16098976 RT Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. RA Lee Y, Lee do H, Kho CW, Lee AY, Jang M, Cho S, Lee CH, Lee JS, Myung PK, Park BC, Park SG RL FEBS Lett. 2005 Aug 29;579(21):4769-74. RN [2] RM PMID: 17085964 RT Mouse Transthyretin-related Protein Is a Hydrolase which Degrades 5-Hydroxyisourate, the End Product of the Uricase Reaction. RA Lee Y, Park BC, Lee do H, Bae KH, Cho S, Lee CH, Lee JS, Myung PK, Park SG RL Mol Cells. 2006 Oct 31;22(2):141-5.
Genome PropertyGenProp0688: urate catabolism to allantoin (HMM)