HMM Summary Page: TIGR02961

Gene Symbolalc
Trusted Cutoff277.90
Domain Trusted Cutoff277.90
Noise Cutoff118.60
Domain Noise Cutoff118.60
Isology Typeequivalog
EC Number3.5.3.4
HMM Length324
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryOther
Gene Ontology TermGO:0000256: allantoin catabolic process biological_process
GO:0004037: allantoicase activity molecular_function
AuthorHaft DH
Entry DateJun 6 2006 10:36PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the enzyme allantoicase (EC, also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (PF03561). A different but similarly named enzyme, allantoate amidohydrolase (EC, simultaneously breaks down the urea to ammonia and carbon dioxide.
ReferencesDR BRENDA; DR URL; DR PFAM; PF03561; Allantoicase repeat DR HAMAP; MF_00813; 20 of 20 RN [1] RM PMID: 10864446 RT Xenopus allantoicase: molecular cloning, enzymatic activity and developmental expression. RA Vigetti D, Monetti C, Pollegioni L, Taramelli R, Bernardini G RL Arch Biochem Biophys. 2000 Jul 1;379(1):90-6.
Genome PropertyGenProp0687: allantoin catabolism to oxamate and carbamoyl-phosphate (HMM)
GenProp0686: allantoin catabolism to glyoxalate and urea (HMM)
GenProp0686: allantoin catabolism to glyoxalate and urea (HMM)