| Accession | TIGR02961 |
| Name | allantoicase |
| Function | allantoicase |
| Gene Symbol | alc |
| Trusted Cutoff | 277.90 |
| Domain Trusted Cutoff | 277.90 |
| Noise Cutoff | 118.60 |
| Domain Noise Cutoff | 118.60 |
| Isology Type | equivalog |
| EC Number | 3.5.3.4 |
| HMM Length | 324 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | Other |
| Gene Ontology Term | GO:0000256: allantoin catabolic process biological_process |
| | GO:0004037: allantoicase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jun 6 2006 10:36PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC 3.5.2.5) hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC 3.5.3.9). Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (PF03561).
A different but similarly named enzyme, allantoate amidohydrolase (EC 3.5.3.9), simultaneously breaks down the urea to ammonia and carbon dioxide. |
| References | DR BRENDA; 3.5.3.4
DR URL; www.brenda.uni-koeln.de/php/result_flat.php4?ecno=3.5.3.4
DR PFAM; PF03561; Allantoicase repeat
DR HAMAP; MF_00813; 20 of 20
RN [1]
RM PMID: 10864446
RT Xenopus allantoicase: molecular cloning, enzymatic activity and developmental expression.
RA Vigetti D, Monetti C, Pollegioni L, Taramelli R, Bernardini G
RL Arch Biochem Biophys. 2000 Jul 1;379(1):90-6. |
| Genome Property | GenProp0687: allantoin catabolism to oxamate and carbamoyl-phosphate (HMM) |
| | GenProp0686: allantoin catabolism to glyoxalate and urea (HMM) |
| | GenProp0686: allantoin catabolism to glyoxalate and urea (HMM) |
