HMM Summary Page: TIGR02950

FunctionRNA polymerase sigma factor, SigM family
Gene Symbol147.95
Trusted Cutoff147.95
Domain Trusted Cutoff129.80
Noise Cutoff129.80
Isology TypeRN [1] RM PMID: 12775685 RT SigM, an extracytoplasmic function sigma factor of Bacillus subtilis, is activated in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress. RA Thackray PD, Moir A. RL J Bacteriol. 2003 Jun;185(12):3491-8. RN [2] RM PMID: 10216858 RT Sigma M, an ECF RNA polymerase sigma factor of Bacillus subtilis 168, is essential for growth and survival in high concentrations of salt. RA Horsburgh MJ, Moir A. RL Mol Microbiol. 1999 Apr;32(1):41-50.
HMM Lengthsubfamily
Mainrole Category159
AuthorSelengut J
Entry DateJun 1 2006 2:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of RNA polymerase sigma factors is a member of the Sigma-70 subfamily (TIGR02937) and is restricted to certain lineages of the order Bacillales. This family encompasses at least two distinct sigma factors as two proteins are found in each of B. anthracis, B. subtilis subsp. subtilis str. 168, and B. lichiniformis (although these are not apparently the same two in each). One of these is designated as SigM in B. subtilis (Swiss_Prot:
ReferencesSIGM_BACSU) and is activated by various stressors [1,2].