HMM Summary Page: TIGR02921

FunctionPEP-CTERM family integral membrane protein
Trusted Cutoff200.00
Domain Trusted Cutoff200.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typehypoth_equivalog
HMM Length922
AuthorHaft DH, Selengut J
Entry DateApr 21 2006 2:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, found in eighteen genera so far, have a PEP-CTERM sequence at the carboxyl-terminus (see model TIGR02595), but are unusual among PEP-CTERM proteins in having multiple predicted transmembrane segments. The function is unknown. It is proposed that an exosortase (see TIGR02602), recognizes and cleaves PEP-CTERM proteins in a manner analogous to the cleavage of LPXTG proteins by sortase (see Haft, et al., 2006). In at least six species, a gene encoding what appears to be a dedicated (single target) exosortase is adjacent. In that subset, the PEP-CTERM motif takes the form VPEPxxWxL.
ReferencesDR TIGRFAMS; TIGR02595; PEP_anchor RN [1] RA Haft DH, Paulsen IT, Ward N, Selengut JD RT Exopolysaccharide-associated protein sorting in environmental organisms by the PEP-CTERM/EpsH system: application of a novel phylogenetic profiling heuristic. RL BMC Biol., in press, 2006