HMM Summary Page: TIGR02914

FunctionEpsI family protein
Gene SymbolepsI
Trusted Cutoff42.80
Domain Trusted Cutoff42.80
Noise Cutoff42.45
Domain Noise Cutoff42.45
Isology Typeequivalog_domain
HMM Length174
Mainrole CategoryTransport and binding proteins
Subrole CategoryUnknown substrate
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005575: cellular_component cellular_component
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateApr 5 2006 10:48AM
Last ModifiedFeb 14 2011 3:27PM
CommentIn Methylobacillus sp strain 12S, EpsI is encoded immediately downstream of the multiple-membrane-spanning putative transporter EpsH, and is predicted to be a periplasmic protein involved in, but not required for, expression of the exopolysaccharide methanolan. In a number of other species, protein homologous to EpsI is encoded either next to EpsH or, more often, combined in a fused gene. We have proposed renaming EpsH, or the EpsHI fusion protein, to exosortase, based on its phylogenetic association with the PEP-CTERM proposed protein targeting signal.
ReferencesRN [1] RM PMID: 16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4(1):29. RN [2] RM PMID: 12624205 RT Genes involved in the synthesis of the exopolysaccharide methanolan by the obligate methylotroph Methylobacillus sp strain 12S. RA Yoshida T, Ayabe Y, Yasunaga M, Usami Y, Habe H, Nojiri H, Omori T RL Microbiology. 2003 Feb;149(Pt 2):431-44.
Genome PropertyGenProp0326: protein sorting system, PEP-CTERM/exosortase (generic) (HMM)
GenProp0652: exopolysaccharide biosynthesis, exosortase A-associated (HMM-CLUST)