HMM Summary Page: TIGR02910

Functionsulfite reductase, subunit A
Gene SymbolasrA
Trusted Cutoff323.15
Domain Trusted Cutoff323.15
Noise Cutoff223.60
Domain Noise Cutoff223.60
Isology Typeequivalog
EC Number1.8.-.-
HMM Length334
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0006790: sulfur compound metabolic process biological_process
GO:0009055: electron carrier activity molecular_function
GO:0016002: sulfite reductase activity molecular_function
AuthorHaft DH
Entry DateMar 24 2006 3:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family include the A subunit, one of three subunits, of the anaerobic sulfite reductase of Salmonella, and close homologs from various Clostridum species, where the three-gene neighborhood is preserved. Two such gene clusters are found in Clostridium perfringens, but it may be that these sets of genes correspond to the distinct assimilatory and dissimilatory forms as seen in Clostridium pasteurianum. Note that any one of these enzymes may have secondary substates such as NH2OH, SeO3(2-), and SO3(2-). Heterologous expression of the anaerobic sulfite reductase of Salmonella confers on Escherichia coli the ability to produce hydrogen sulfide gas from sulfite.
ReferencesRN [1] RM PMID: 1704886 RT Sequence analysis and expression of the Salmonella typhimurium asr operon encoding production of hydrogen sulfide from sulfite. RA Huang CJ, Barrett EL RL J Bacteriol. 1991 Feb;173(4):1544-53. RN [2] RM PMID: 667738 RT Stable isotope fractionation by Clostridium pasteurianum. 2. Regulation of sulfite reductases by sulfur amino acids and their influence on sulfur isotope fractionation during SO32- and SO42- reduction. RA Laishley EJ, Krouse HR RL Can J Microbiol. 1978 Jun;24(6):716-24. RN [3] RM PMID: 6742957 RT Purification and characterization of an inducible dissimilatory type sulfite reductase from Clostridium pasteurianum. RA Harrison G, Curle C, Laishley EJ RL Arch Microbiol. 1984 May;138(1):72-8.
Genome PropertyGenProp0624: sulfite reductase complex, Salmonella/Clostridium type (HMM)