| Accession | TIGR02902 |
| Name | spore_lonB |
| Function | ATP-dependent protease LonB |
| Gene Symbol | lonB |
| Trusted Cutoff | 723.30 |
| Domain Trusted Cutoff | 723.30 |
| Noise Cutoff | 595.10 |
| Domain Noise Cutoff | 595.10 |
| Isology Type | equivalog |
| EC Number | 3.4.21.- |
| HMM Length | 531 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0004252: serine-type endopeptidase activity molecular_function |
| | GO:0006508: proteolysis biological_process |
| | GO:0016887: ATPase activity molecular_function |
| | GO:0030436: asexual sporulation biological_process |
| Author | Haft DH |
| Entry Date | Mar 21 2006 10:56AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein are LonB, a paralog of the ATP-dependent protease La (LonA, TIGR00763). LonB proteins are found strictly, and almost universally, in endospore-forming bacteria. This protease was shown, in Bacillus subtilis, to be expressed specifically in the forespore, during sporulation, under control of sigma(F). The lonB gene, despite location immediately upstream of lonA, was shown to be monocistronic. LonB appears able to act on sigma(H) for post-translation control, but lonB mutation did not produce an obvious sporulation defect under the conditions tested. Note that additional paralogs of LonA and LonB occur in the Clostridium lineage and this model selects only one per species as the protein that corresponds to LonB in B. subtilis. |
| References | RN [1]
RM PMID: 11325926
RT Forespore-specific transcription of the lonB gene during sporulation in Bacillus subtilis.
RA Serrano M, Hovel S, Moran CP Jr, Henriques AO, Volker U
RL J Bacteriol. 2001 May;183(10):2995-3003.
RN [2]
RM PMID: 10411757
RT Role of lon and ClpX in the post-translational regulation of a sigma subunit of RNA polymerase required for cellular differentiation in Bacillus subtilis.
RA Liu J, Cosby WM, Zuber P
RL Mol Microbiol. 1999 Jul;33(2):415-28. |
| Genome Property | GenProp0610: endospore formation marker gene set (HMM) |
