HMM Summary Page: TIGR02902

FunctionATP-dependent protease LonB
Gene SymbollonB
Trusted Cutoff723.30
Domain Trusted Cutoff723.30
Noise Cutoff595.10
Domain Noise Cutoff595.10
Isology Typeequivalog
EC Number3.4.21.-
HMM Length531
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004252: serine-type endopeptidase activity molecular_function
GO:0006508: proteolysis biological_process
GO:0016887: ATPase activity molecular_function
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 21 2006 10:56AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein are LonB, a paralog of the ATP-dependent protease La (LonA, TIGR00763). LonB proteins are found strictly, and almost universally, in endospore-forming bacteria. This protease was shown, in Bacillus subtilis, to be expressed specifically in the forespore, during sporulation, under control of sigma(F). The lonB gene, despite location immediately upstream of lonA, was shown to be monocistronic. LonB appears able to act on sigma(H) for post-translation control, but lonB mutation did not produce an obvious sporulation defect under the conditions tested. Note that additional paralogs of LonA and LonB occur in the Clostridium lineage and this model selects only one per species as the protein that corresponds to LonB in B. subtilis.
ReferencesRN [1] RM PMID: 11325926 RT Forespore-specific transcription of the lonB gene during sporulation in Bacillus subtilis. RA Serrano M, Hovel S, Moran CP Jr, Henriques AO, Volker U RL J Bacteriol. 2001 May;183(10):2995-3003. RN [2] RM PMID: 10411757 RT Role of lon and ClpX in the post-translational regulation of a sigma subunit of RNA polymerase required for cellular differentiation in Bacillus subtilis. RA Liu J, Cosby WM, Zuber P RL Mol Microbiol. 1999 Jul;33(2):415-28.
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)