HMM Summary Page: TIGR02899

Functionspore coat assembly protein SafA
Gene SymbolsafA
Trusted Cutoff67.85
Domain Trusted Cutoff67.85
Noise Cutoff58.90
Domain Noise Cutoff58.90
Isology Typesubfamily_domain
HMM Length44
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 17 2006 1:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentSafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see PFAM model PF01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. Because lysin motifs are repeated in many proteins, this model is built as a single-hit (-g option, hmms style) model.
ReferencesRN [1] RM PMID: 11325931 RT SpoVID guides SafA to the spore coat in Bacillus subtilis. RA Ozin AJ, Samford CS, Henriques AO, Moran CP Jr RL J Bacteriol. 2001 May;183(10):3041-9. RN [2] RM PMID: 12480901 RT Proteomics characterization of novel spore proteins of Bacillus subtilis. RA Kuwana R, Kasahara Y, Fujibayashi M, Takamatsu H, Ogasawara N, Watabe K RL Microbiology. 2002 Dec;148(Pt 12):3971-82. DR PFAM; PF01476; LysM domain
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)