HMM Summary Page: TIGR02890

Functionregulatory protein, yteA family
Trusted Cutoff134.40
Domain Trusted Cutoff134.40
Noise Cutoff128.80
Domain Noise Cutoff128.80
Isology Typesubfamily
HMM Length159
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 13 2006 4:05PM
Last ModifiedFeb 29 2012 11:48AM
CommentMembers of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to PFAM family PF01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved.
ReferencesDR PF01258; zf-dskA_traR RN [1] RM PMID:21255113 RT Role of a Zn-independent DksA in Zn homeostasis and stringent response. RA Blaby-Haas CE, Furman R, Rodionov DA, Artsimovitch I, de Crecy-Lagard V RL Mol Microbiol. 2011 Feb;79(3):700-15.