HMM Summary Page: TIGR02883

FunctionN-acetylmuramoyl-L-alanine amidase CwlD
Gene SymbolcwlD
Trusted Cutoff221.55
Domain Trusted Cutoff221.55
Noise Cutoff142.10
Domain Noise Cutoff142.10
Isology Typeequivalog
EC Number3.5.1.28
HMM Length189
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008745: N-acetylmuramoyl-L-alanine amidase activity molecular_function
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 9 2006 4:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the CwlD family of N-acetylmuramoyl-L-alanine amidase. This family has been called the germination-specific N-acetylmuramoyl-L-alanine amidase. CwlD is required, along with the putative deactylase PdaA, to make muramic delta-lactam, a novel peptidoglycan constituent found only in spores. CwlD mutants show a germination defect.
ReferencesRN [1] RM 14679227 RT Production of muramic delta-lactam in Bacillus subtilis spore peptidoglycan. RA Gilmore ME, Bandyopadhyay D, Dean AM, Linnstaedt SD, Popham DL. RL J Bacteriol. 2004 Jan;186(1):80-9.