HMM Summary Page: TIGR02866

Functioncytochrome c oxidase, subunit II
Gene SymbolcoxB
Trusted Cutoff147.70
Domain Trusted Cutoff147.70
Noise Cutoff144.30
Domain Noise Cutoff144.30
Isology Typeequivalog
EC Number1.9.3.1
HMM Length202
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0004129: cytochrome-c oxidase activity molecular_function
GO:0055114: oxidation-reduction process biological_process
AuthorSelengut J
Entry DateMar 6 2006 10:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentCytochrome c oxidase is the terminal electron acceptor of mitochondria (and one of several possible acceptors in prokaryotes) in the electron transport chain of aerobic respiration. The enzyme couples the oxidation of reduced cytochrome c with the reduction of molecular oxygen to water. This process results in the pumping of four protons across the membrane which are used in the proton gradient powered synthesis of ATP. The oxidase contains two heme a cofactors and three copper atoms as well as other bound ions [1].
ReferencesRN [1] RM PMID: 9380672 RT Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment. RA Ostermeier C, Harrenga A, Ermler U, Michel H. RL Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10547-53.
Genome PropertyGenProp0614: cytochrome c oxidase, mitochondrial, caa3-type (HMM)