HMM Summary Page: TIGR02865

Functionstage II sporulation protein E
Gene SymbolspoIIE
Trusted Cutoff490.80
Domain Trusted Cutoff490.80
Noise Cutoff201.15
Domain Noise Cutoff201.15
Isology Typeequivalog
EC Number3.1.3.16
HMM Length764
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
Gene Ontology TermGO:0004722: protein serine/threonine phosphatase activity molecular_function
GO:0016020: membrane cellular_component
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 6 2006 8:43AM
Last ModifiedFeb 14 2011 3:27PM
CommentStage II sporulation protein E (SpoIIE) is a multiple membrane spanning protein with two separable functions. It plays a role in the switch to polar cell division during sporulation. By means of it protein phosphatase activity, located in the C-terminal region, it activates sigma-F. All proteins that score above the trusted cutoff to this model are found in endospore-forming Gram-positive bacteria. Surprisingly, a sequence from the Cyanobacterium-like (and presumably non-spore-forming) photosynthesizer Heliobacillus mobilis is homologous, and scores between the trusted and noise cutoffs.
ReferencesRN [1] RM 15866939 RT Genetic dissection of the sporulation protein SpoIIE and its role in asymmetric division in Bacillus subtilis. RA Carniol K, Ben-Yehuda S, King N, Losick R. RL J Bacteriol. 2005 May;187(10):3511-20.
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)