HMM Summary Page: TIGR02862

Functionpro-sigmaK processing inhibitor BofA
Gene SymbolbofA
Trusted Cutoff53.35
Domain Trusted Cutoff53.35
Noise Cutoff34.00
Domain Noise Cutoff34.00
Isology Typesubfamily
HMM Length83
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
Gene Ontology TermGO:0016020: membrane cellular_component
GO:0030436: asexual sporulation biological_process
AuthorHaft DH
Entry DateMar 3 2006 1:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K.
ReferencesRN [1] RM 11959848 RT A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization. RA Rudner DZ, Losick R. RL Genes Dev. 2002 Apr 15;16(8):1007-18.