HMM Summary Page: TIGR02857

Functionthiol reductant ABC exporter, CydD subunit
Gene SymbolcydD
Trusted Cutoff435.00
Domain Trusted Cutoff435.00
Noise Cutoff435.00
Domain Noise Cutoff435.00
Isology Typeequivalog
HMM Length529
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0005887: integral to plasma membrane cellular_component
GO:0033228: cysteine export biological_process
GO:0033230: cysteine-transporting ATPase activity molecular_function
GO:0055051: ATP-binding cassette (ABC) transporter complex, integrated substrate binding cellular_component
AuthorSelengut J
Entry DateMar 2 2006 2:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (PF00664) and a C-terminal ATP-binding domain (PF00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione [1,2]. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD
ReferencesRN [1] RM PMID: 16040611 RT A bacterial glutathione transporter (Escherichia coli CydDC) exports reductant to the periplasm. RA Pittman MS, Robinson HC, Poole RK. RL J Biol Chem. 2005 Sep 16;280(37):32254-61. Epub 2005 Jul 22. RN [2] RM PMID: 12393891 RT Cysteine is exported from the Escherichia coli cytoplasm by CydDC, an ATP-binding cassette-type transporter required for cytochrome assembly. RA Pittman MS, Corker H, Wu G, Binet MB, Moir AJ, Poole RK. RL J Biol Chem. 2002 Dec 20;277(51):49841-9. Epub 2002 Oct 21. RN [3] RM PMID: 9335308 RT Transcriptional regulation of the cydDC operon, encoding a heterodimeric ABC transporter required for assembly of cytochromes c and bd in Escherichia coli K-12: regulation by oxygen and alternative electron acceptors. RA Cook GM, Membrillo-Hernandez J, Poole RK. RL J Bacteriol. 1997 Oct;179(20):6525-30.
Genome PropertyGenProp0617: cytochrome (quinone) oxidase, bd type (HMM)