HMM Summary Page: TIGR02827

Functionanaerobic ribonucleoside-triphosphate reductase
Gene SymbolnrdD
Trusted Cutoff568.30
Domain Trusted Cutoff568.30
Noise Cutoff197.75
Domain Noise Cutoff197.75
Isology Typeequivalog
EC Number1.17.4.2
HMM Length596
AuthorHaft DH
Entry DateFeb 17 2006 11:25AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family belong to the class III anaerobic ribonucleoside-triphosphate reductases (RNR). These glycine-radical-containing enzymes are oxygen-sensitive and operate under anaerobic conditions. The genes for this family are pair with genes for an acitivating protein that creates a glycine radical. Members of this family, though related, fall outside the scope of TIGR02487, a functionally equivalent protein set; no genome has members in both familes. Identification as RNR is supported by gene pairing with the activating protein, lack of other anaerobic RNR, and presence of an upstream regulatory element strongly conserved upstream of most RNR operons.
ReferencesRN [1] RM 15949864 RT Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling. RA Rodionov DA, Gelfand MS. RL Trends Genet. 2005 Jul;21(7):385-9.
Genome PropertyGenProp0291: class III (anaerobic) ribonucleotide reductase (HMM)