HMM Summary Page: TIGR02825

Functionleukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
Trusted Cutoff579.85
Domain Trusted Cutoff579.85
Noise Cutoff314.35
Domain Noise Cutoff314.35
Isology Typeequivalog
EC Number1.3.1.74
HMM Length327
AuthorHaft DH
Entry DateFeb 14 2006 2:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentLeukotriene B4 12-hydroxydehydrogenase is an NADP-dependent enzyme of arachidonic acid metabolism, responsible for converting leukotriene B4 to the much less active metabolite 12-oxo-leukotriene B4. The BRENDA database lists leukotriene B4 12-hydroxydehydrogenase as one of the synonyms of 2-alkenal reductase (EC, while is 15-oxoprostaglandin 13-reductase.
ReferencesRN [1] RM 15007077 RT Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. RA Hori T, Yokomizo T, Ago H, Sugahara M, Ueno G, Yamamoto M, Kumasaka T, Shimizu T, Miyano M. RL J Biol Chem. 2004 May 21;279(21):22615-23. RN [2] RM 8576264 RT cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. RA Yokomizo T, Ogawa Y, Uozumi N, Kume K, Izumi T, Shimizu T. RL J Biol Chem. 1996 Feb 2;271(5):2844-50. DR BRRENDA;; 2-alkenal reductase