HMM Summary Page: TIGR02823

Functionputative quinone oxidoreductase, YhdH/YhfP family
Trusted Cutoff297.25
Domain Trusted Cutoff297.25
Noise Cutoff146.90
Domain Noise Cutoff146.90
Isology Typesubfamily
HMM Length324
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008152: metabolic process biological_process
GO:0016655: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor molecular_function
AuthorHaft DH
Entry DateFeb 13 2006 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a subfamily of PF00107 as defined by Pfam, a superfamily in which some members are zinc-binding medium-chain alcohol dehydrogenases while others are quinone oxidoreductases with no bound zinc. This subfamily includes proteins studied crystallographically for insight into function: YhdH from Escherichia coli and YhfP from Bacillus subtilis. Members bind NADPH or NAD, but not zinc.
ReferencesRN [1] RM 15388933 RT Structure of Escherichia coli YhdH, a putative quinone oxidoreductase. RA Sulzenbacher G, Roig-Zamboni V, Pagot F, Grisel S, Salomoni A, Valencia C, Campanacci V, Vincentelli R, Tegoni M, Eklund H, Cambillau C. RL Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1855-62. RN [2] RT The crystal structure of hypothetical protein yhfP from Bacillus subtilis RA Min, T., Gorman, J., Shapiro, L. RL unpublished