| Accession | TIGR02821 |
| Name | fghA_ester_D |
| Function | S-formylglutathione hydrolase |
| Gene Symbol | fghA |
| Trusted Cutoff | 281.70 |
| Domain Trusted Cutoff | 281.70 |
| Noise Cutoff | 131.95 |
| Domain Noise Cutoff | 131.95 |
| Isology Type | equivalog |
| EC Number | 3.1.2.12 |
| HMM Length | 275 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Gene Ontology Term | GO:0018738: S-formylglutathione hydrolase activity molecular_function |
| | GO:0046292: formaldehyde metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Feb 9 2006 10:59PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. |
| References | RN [1]
RM 8892832
RT S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?
RA Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH.
RL J Bacteriol. 1996 Nov;178(21):6296-9. |
| Genome Property | GenProp0562: formaldehyde detoxification, glutathione-dependent (HMM) |
