Accession | TIGR02818 |
Name | adh_III_F_hyde |
Function | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase |
Trusted Cutoff | 543.95 |
Domain Trusted Cutoff | 543.95 |
Noise Cutoff | 509.55 |
Domain Noise Cutoff | 509.55 |
Isology Type | equivalog |
EC Number | 1.1.1.284 1.1.1.1 |
HMM Length | 368 |
Mainrole Category | Cellular processes |
Subrole Category | Detoxification |
Gene Ontology Term | GO:0004024: alcohol dehydrogenase activity, zinc-dependent molecular_function |
| GO:0006113: fermentation biological_process |
| GO:0009404: toxin metabolic process biological_process |
| GO:0051903: S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function |
Author | Haft DH |
Entry Date | Feb 8 2006 11:28AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The members of this protein family show dual function. First, they remove formaldehyde, a toxic metabolite, by acting as S-(hydroxymethyl)glutathione dehydrogenase (1.1.1.284). S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and so this enzyme previously was designated glutathione-dependent formaldehyde dehydrogenase. These same proteins are also designated alcohol dehydrogenase (EC 1.1.1.1) of class III, for activities that do not require glutathione; they tend to show poor activity for ethanol among their various substrate alcohols. |
Genome Property | GenProp0562: formaldehyde detoxification, glutathione-dependent (HMM) |