HMM Summary Page: TIGR02818

FunctionS-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
Trusted Cutoff543.95
Domain Trusted Cutoff543.95
Noise Cutoff509.55
Domain Noise Cutoff509.55
Isology Typeequivalog
EC Number1.1.1.284
HMM Length368
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0004024: alcohol dehydrogenase activity, zinc-dependent molecular_function
GO:0006113: fermentation biological_process
GO:0009404: toxin metabolic process biological_process
GO:0051903: S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function
AuthorHaft DH
Entry DateFeb 8 2006 11:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe members of this protein family show dual function. First, they remove formaldehyde, a toxic metabolite, by acting as S-(hydroxymethyl)glutathione dehydrogenase ( S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and so this enzyme previously was designated glutathione-dependent formaldehyde dehydrogenase. These same proteins are also designated alcohol dehydrogenase (EC of class III, for activities that do not require glutathione; they tend to show poor activity for ethanol among their various substrate alcohols.
Genome PropertyGenProp0562: formaldehyde detoxification, glutathione-dependent (HMM)