| Accession | TIGR02818 |
| Name | adh_III_F_hyde |
| Function | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase |
| Trusted Cutoff | 543.95 |
| Domain Trusted Cutoff | 543.95 |
| Noise Cutoff | 509.55 |
| Domain Noise Cutoff | 509.55 |
| Isology Type | equivalog |
| EC Number | 1.1.1.284 1.1.1.1 |
| HMM Length | 368 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Gene Ontology Term | GO:0004024: alcohol dehydrogenase activity, zinc-dependent molecular_function |
| | GO:0006113: fermentation biological_process |
| | GO:0009404: toxin metabolic process biological_process |
| | GO:0051903: S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function |
| Author | Haft DH |
| Entry Date | Feb 8 2006 11:28AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The members of this protein family show dual function. First, they remove formaldehyde, a toxic metabolite, by acting as S-(hydroxymethyl)glutathione dehydrogenase (1.1.1.284). S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and so this enzyme previously was designated glutathione-dependent formaldehyde dehydrogenase. These same proteins are also designated alcohol dehydrogenase (EC 1.1.1.1) of class III, for activities that do not require glutathione; they tend to show poor activity for ethanol among their various substrate alcohols. |
| Genome Property | GenProp0562: formaldehyde detoxification, glutathione-dependent (HMM) |
