HMM Summary Page: TIGR02812

Functionfatty acid metabolism transcriptional regulator FadR
Gene SymbolfadR
Trusted Cutoff249.20
Domain Trusted Cutoff249.20
Noise Cutoff85.40
Domain Noise Cutoff85.40
Isology Typeequivalog
HMM Length235
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0019217: regulation of fatty acid metabolic process biological_process
AuthorHaft DH
Entry DateFeb 1 2006 10:33AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are FadR, a transcriptional regulator of fatty acid metabolism, including both biosynthesis and beta-oxidation. It is found exclusively in a subset of Gammaproteobacteria, with strictly one copy per genome. It has an N-terminal DNA-binding domain and a less well conserved C-terminal long chain acyl-CoA-binding domain. FadR from this family heterologously expressed in Escherichia coli show differences in regulatory response and fatty acid binding profiles. The family is nevertheless designated equivalog, as all member proteins have at least nominally the same function.
ReferencesDR PFAM; PF00392; GntR; transcriptional regulator, GntR family DR PFAM; PF07840; FadR_C; FadR C-terminal domain RM 16027119 RT Unexpected functional diversity among FadR fatty acid transcriptional regulatory proteins. RA Iram SH, Cronan JE. RL J Biol Chem. 2005 Sep 16;280(37):32148-56. DR HAMAP; MF_00696; 52 of 54