Accession | TIGR02812 |
Name | fadR_gamma |
Function | fatty acid metabolism transcriptional regulator FadR |
Gene Symbol | fadR |
Trusted Cutoff | 249.20 |
Domain Trusted Cutoff | 249.20 |
Noise Cutoff | 85.40 |
Domain Noise Cutoff | 85.40 |
Isology Type | equivalog |
HMM Length | 235 |
Mainrole Category | Fatty acid and phospholipid metabolism |
Subrole Category | Biosynthesis |
Gene Ontology Term | GO:0003700: sequence-specific DNA binding transcription factor activity molecular_function |
| GO:0006355: regulation of transcription, DNA-dependent biological_process |
| GO:0019217: regulation of fatty acid metabolic process biological_process |
Author | Haft DH |
Entry Date | Feb 1 2006 10:33AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this family are FadR, a transcriptional regulator of fatty acid metabolism, including both biosynthesis and beta-oxidation. It is found exclusively in a subset of Gammaproteobacteria, with strictly one copy per genome. It has an N-terminal DNA-binding domain and a less well conserved C-terminal long chain acyl-CoA-binding domain. FadR from this family heterologously expressed in Escherichia coli show differences in regulatory response and fatty acid binding profiles. The family is nevertheless designated equivalog, as all member proteins have at least nominally the same function. |
References | DR PFAM; PF00392; GntR; transcriptional regulator, GntR family
DR PFAM; PF07840; FadR_C; FadR C-terminal domain
RM 16027119
RT Unexpected functional diversity among FadR fatty acid transcriptional regulatory proteins.
RA Iram SH, Cronan JE.
RL J Biol Chem. 2005 Sep 16;280(37):32148-56.
DR HAMAP; MF_00696; 52 of 54 |