HMM Summary Page: TIGR02810

FunctionD-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
Trusted Cutoff568.80
Domain Trusted Cutoff568.80
Noise Cutoff191.60
Domain Noise Cutoff191.60
Isology Typeequivalog
EC Number4.1.2.40
HMM Length420
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
AuthorHaft DH
Entry DateJan 30 2006 2:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentAldolases specific for D-tagatose-bisphosphate occur in distinct pathways in Escherichia coli and other bacteria, one for the degradation of galactitol (formerly dulcitol) and one for degradation of N-acetyl-galactosamine and D-galactosamine. This family represents a protein of both systems that behaves as a non-catalytic subunit of D-tagatose-bisphosphate aldolase, required both for full activity and for good stability of the aldolase. Note that members of this protein family appear in public databases annotated as putative tagatose 6-phosphate kinases, possibly in error.
ReferencesRN [1] RM 11976750 RT Two class II D-tagatose-bisphosphate aldolases from enteric bacteria. RA Brinkkotter A, Shakeri-Garakani A, Lengeler JW. RL Arch Microbiol. 2002 May;177(5):410-9. RN [2] RM 8955298 RT Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism. RA Nobelmann B, Lengeler JW. RL J Bacteriol. 1996 Dec;178(23):6790-5. RN [3] RM 10931310 RT Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli. RA Brinkkotter A, Kloss H, Alpert C, Lengeler JW. RL Mol Microbiol. 2000 Jul;37(1):125-35.