HMM Summary Page: TIGR02806

Gene SymbolcloSI
Trusted Cutoff436.25
Domain Trusted Cutoff436.25
Noise Cutoff60.25
Domain Noise Cutoff60.25
Isology Typeequivalog
EC Number3.4.22.8
HMM Length472
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0006508: proteolysis biological_process
GO:0051404: clostripain activity molecular_function
AuthorHaft DH
Entry DateJan 24 2006 1:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentClostripain is a cysteine protease characterized from Clostridium histolyticum, and also known from Clostridium perfringens. It is a heterodimer processed from a single precursor polypeptide, specific for Arg-|-Xaa peptide bonds. The older term alpha-clostripain refers to the most active, most reduced form, rather than to the product of one of several different genes. Clostripain belongs to the peptidase family C11, or clostripain family (see PF03415).
ReferencesRN [1] RM 762145 RT alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain. RA Gilles AM, Imhoff JM, Keil B. RL J Biol Chem. 1979 Mar 10;254(5):1462-8. RN [2] RM 11976286 RT Proteome and transcriptome analysis of the virulence genes regulated by the VirR/VirS system in Clostridium perfringens. RA Shimizu T, Shima K, Yoshino K, Yonezawa K, Shimizu T, Hayashi H. RL J Bacteriol. 2002 May;184(10):2587-94. DR PFAM; PF03415; Peptidase_C11; Clostripain family DR SWISSPROT; P09870; Clostridium histolyticum