HMM Summary Page: TIGR02799

Functiontol-pal system-associated acyl-CoA thioesterase
Gene SymbolybgC
Trusted Cutoff141.35
Domain Trusted Cutoff141.35
Noise Cutoff88.85
Domain Noise Cutoff88.85
Isology Typeequivalog
EC Number3.1.2.-
HMM Length126
Gene Ontology TermGO:0005515: protein binding molecular_function
GO:0005737: cytoplasm cellular_component
GO:0016291: acyl-CoA thioesterase activity molecular_function
AuthorHaft DH
Entry DateJan 20 2006 1:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe tol-pal system consists of five critical genes. Inner membrane proteins TolQ and TolR convert protomotive force to energy that is transduced through TolA to an outer membrane complex of TolB and Pal. The system is known to be required to maintain outer membrane integrity. In a system with several homologous parts, ExbB and ExbD transduces energy through TonB to a variety of outer membrane proteins, many of which are siderophore receptors. The tol-pal system therefore may also be involved in transport. This family consists of a protein nearly always found in operons with the genes of the tol-pal system. The significance of this thioesterase to the tol-pal system is unclear, but either of two observations may be relevant. First, Pal, or peptidoglycan-associated lipoprotein, has a conserved N-terminal cleavage and acylation that makes it a lipoprotein. Second, the tol-pal system is implicated not only in the import of certain organics but also in the maintenance of outer membrane integrity (by an unknown mechanism).
ReferencesRN [1] RM 11959124 RT The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis. RA Zhuang Z, Song F, Martin BM, Dunaway-Mariano D. RL FEBS Lett. 2002 Apr 10;516(1-3):161-3.
Genome PropertyGenProp0542: Tol-Pal system (HMM)