HMM Summary Page: TIGR02798

Function4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase
Gene SymbolligK
Trusted Cutoff304.50
Domain Trusted Cutoff304.50
Noise Cutoff215.55
Domain Noise Cutoff215.55
Isology Typeequivalog
EC Number4.1.-.-
HMM Length222
AuthorHaft DH
Entry DateJan 20 2006 11:46AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family 4-carboxy-4-hydroxy-2-oxoadipate aldolase, also called 4-oxalocitramalate aldolase. This enzyme of the protocatechuate 4,5-cleavage pathway converts its substrate to pyruvate plus oxaloacetate. Protocatechuate is an intermediate in many pathways for degrading aromatic compounds, including lignin, fluorene, etc. Hara, et al. showed the LigK gene was not only a 4-carboxy-4-hydroxy-2-oxoadipate aldolase but also the enzyme of the following step, oxaloacetate decarboxylase.
ReferencesRN [1] RM 12486039 RT Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6. RA Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M. RL J Bacteriol. 2003 Jan;185(1):41-50.