| Accession | TIGR02793 |
| Name | nikR |
| Function | nickel-responsive transcriptional regulator NikR |
| Gene Symbol | nikR |
| Trusted Cutoff | 175.45 |
| Domain Trusted Cutoff | 175.45 |
| Noise Cutoff | 71.75 |
| Domain Noise Cutoff | 71.75 |
| Isology Type | equivalog |
| HMM Length | 129 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0003677: DNA binding molecular_function |
| | GO:0005737: cytoplasm cellular_component |
| | GO:0010045: response to nickel cation biological_process |
| | GO:0016151: nickel cation binding molecular_function |
| | GO:0016564: transcription repressor activity molecular_function |
| Author | Haft DH |
| Entry Date | Jan 17 2006 2:08PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Three members of the seed for this model, from Escherichia coli, Pseudomonas putida, and Brucella melitensis, are found associated with a nickel ABC transporter operon that acts to import nickel for use as a cofactor in urease or hydrogenase. These proteins, with characterized nickel-binding and DNA-binding domains, act as nickel-responsive transcriptional regulators. In the larger family of full-length homologs, most others both lack proximity to the nickel ABC transporter operon and form a separate clade. Several of the homologs not within the scope of this model, but rather scoring between the trusted and noise cutoffs, have been shown to bind nickel, copper, or both, and to regulate genes in response to nickel. |
| References | DR PFAM; PF01402; Ribbon-helix-helix protein, copG family
DR HAMAP; MF_00476; 31 of 80 |
| Genome Property | GenProp0494: nickel import ABC transporter (HMM) |
