HMM Summary Page: TIGR02793

Functionnickel-responsive transcriptional regulator NikR
Gene SymbolnikR
Trusted Cutoff175.45
Domain Trusted Cutoff175.45
Noise Cutoff71.75
Domain Noise Cutoff71.75
Isology Typeequivalog
HMM Length129
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0005737: cytoplasm cellular_component
GO:0010045: response to nickel cation biological_process
GO:0016151: nickel cation binding molecular_function
GO:0016564: transcription repressor activity molecular_function
AuthorHaft DH
Entry DateJan 17 2006 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThree members of the seed for this model, from Escherichia coli, Pseudomonas putida, and Brucella melitensis, are found associated with a nickel ABC transporter operon that acts to import nickel for use as a cofactor in urease or hydrogenase. These proteins, with characterized nickel-binding and DNA-binding domains, act as nickel-responsive transcriptional regulators. In the larger family of full-length homologs, most others both lack proximity to the nickel ABC transporter operon and form a separate clade. Several of the homologs not within the scope of this model, but rather scoring between the trusted and noise cutoffs, have been shown to bind nickel, copper, or both, and to regulate genes in response to nickel.
ReferencesDR PFAM; PF01402; Ribbon-helix-helix protein, copG family DR HAMAP; MF_00476; 31 of 80
Genome PropertyGenProp0494: nickel import ABC transporter (HMM)