HMM Summary Page: TIGR02787

FunctionGTP-sensing transcriptional pleiotropic repressor CodY
Gene SymbolcodY
Trusted Cutoff267.20
Domain Trusted Cutoff267.20
Noise Cutoff133.85
Domain Noise Cutoff133.85
Isology Typeequivalog
HMM Length251
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0005525: GTP binding molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0016597: amino acid binding molecular_function
AuthorHaft DH
Entry DateJan 13 2006 12:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by PF08222 in Pfam.
ReferencesDR PFAM; PF06018; CodY; CodY GAF-like domain DR PFAM; PF08222; HTH_CodY; CodY helix-turn-helix domain DR SWISSPROT; P39779; Bacillus subtilis RN [1] RM 15802253 RT CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria. RA Sonenshein AL. RL Curr Opin Microbiol. 2005 Apr;8(2):203-7. DR HAMAP; MF_00621; 70 of 70