HMM Summary Page: TIGR02785

Functionhelicase-exonuclease AddAB, AddA subunit
Gene SymboladdA
Trusted Cutoff707.65
Domain Trusted Cutoff707.65
Noise Cutoff379.80
Domain Noise Cutoff379.80
Isology Typeequivalog
EC Number3.1.-.-
HMM Length1234
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination biological_process
GO:0004003: ATP-dependent DNA helicase activity molecular_function
GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function
AuthorHaft DH
Entry DateJan 11 2006 5:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentAddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species.
ReferencesRN [1] RM 15547262 RT The recombination genes addAB are not restricted to gram-positive bacteria: genetic analysis of the recombination initiation enzymes RecF and AddAB in Rhizobium etli. RA Zuniga-Castillo J, Romero D, Martinez-Salazar JM. RL J Bacteriol. 2004 Dec;186(23):7905-13.
Genome PropertyGenProp0493: addAB pathway (HMM)