| Accession | TIGR02785 |
| Name | addA_Gpos |
| Function | helicase-exonuclease AddAB, AddA subunit |
| Gene Symbol | addA |
| Trusted Cutoff | 707.65 |
| Domain Trusted Cutoff | 707.65 |
| Noise Cutoff | 379.80 |
| Domain Noise Cutoff | 379.80 |
| Isology Type | equivalog |
| EC Number | 3.1.-.- 3.6.4.12 |
| HMM Length | 1234 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0000724: double-strand break repair via homologous recombination biological_process |
| | GO:0004003: ATP-dependent DNA helicase activity molecular_function |
| | GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function |
| Author | Haft DH |
| Entry Date | Jan 11 2006 5:51PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. |
| References | RN [1]
RM 15547262
RT The recombination genes addAB are not restricted to gram-positive bacteria: genetic analysis of the recombination initiation enzymes RecF and AddAB in Rhizobium etli.
RA Zuniga-Castillo J, Romero D, Martinez-Salazar JM.
RL J Bacteriol. 2004 Dec;186(23):7905-13. |
| Genome Property | GenProp0493: addAB pathway (HMM) |
