HMM Summary Page: TIGR02784

Functiondouble-strand break repair helicase AddA
Gene SymboladdA
Trusted Cutoff860.75
Domain Trusted Cutoff860.75
Noise Cutoff357.85
Domain Noise Cutoff357.85
Isology Typeequivalog
HMM Length1138
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination biological_process
AuthorHaft DH
Entry DateJan 11 2006 5:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentAddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species.
ReferencesRN [1] RM 15547262 RT The recombination genes addAB are not restricted to gram-positive bacteria: genetic analysis of the recombination initiation enzymes RecF and AddAB in Rhizobium etli. RA Zuniga-Castillo J, Romero D, Martinez-Salazar JM. RL J Bacteriol. 2004 Dec;186(23):7905-13.
Genome PropertyGenProp0493: addAB pathway (HMM)