| Accession | TIGR02779 |
| Name | NHEJ_ligase_lig |
| Function | DNA ligase D, ligase domain |
| Gene Symbol | ligD |
| Trusted Cutoff | 227.75 |
| Domain Trusted Cutoff | 227.75 |
| Noise Cutoff | 206.40 |
| Domain Noise Cutoff | 206.40 |
| Isology Type | equivalog_domain |
| EC Number | 6.5.1.1 |
| HMM Length | 302 |
| Author | Haft DH |
| Entry Date | Jan 10 2006 1:41PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | DNA repair of double-stranded breaks by non-homologous end joining (NHEJ) is accomplished by a two-protein system that is present in a minority of prokaryotes. One component is the Ku protein (see TIGR02772), which binds DNA ends. The other is a DNA ligase, a protein that is a multidomain polypeptide in most of those bacteria that have NHEJ, a permuted polypeptide in Mycobacterium tuberculosis and a few other species, and the product of tandem genes in some other bacteria. This model represents the ligase domain. |
| References | RN [1]
RM 16046407
RT Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme.
RA Zhu H, Wang LK, Shuman S.
RL J Biol Chem. 2005 Oct 7;280(40):33707-15. |
| Genome Property | GenProp0492: nonhomologous end-joining, bacterial type (HMM) |
