HMM Summary Page: TIGR02777

FunctionDNA ligase D, 3'-phosphoesterase domain
Gene SymbolligD
Trusted Cutoff144.00
Domain Trusted Cutoff144.00
Noise Cutoff65.70
Domain Noise Cutoff65.70
Isology Typeequivalog_domain
HMM Length156
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
AuthorHaft DH
Entry DateJan 10 2006 12:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentMost sequences in this family are the 3'-phosphoesterase domain of a multidomain, multifunctional DNA ligase, LigD, involved, along with bacterial Ku protein, in non-homologous end joining, the less common of two general mechanisms of repairing double-stranded breaks in DNA sequences. LigD is variable in architecture, as it lacks this domain in Bacillus subtilis, is permuted in Mycobacterium tuberculosis, and occasionally is encoded by tandem ORFs rather than as a multifuntional protein. In a few species (Dehalococcoides ethenogenes and the archaeal genus Methanosarcina), sequences corresponding to the ligase and polymerase domains of LigD are not found, and the role of this protein is unclear.
ReferencesRN [1] RM 16046407 RT Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. RA Zhu H, Wang LK, Shuman S. RL J Biol Chem. 2005 Oct 7;280(40):33707-15.
Genome PropertyGenProp0492: nonhomologous end-joining, bacterial type (HMM)