HMM Summary Page: TIGR02774

FunctionATP-dependent nuclease subunit B
Gene SymbolrexB
Trusted Cutoff718.35
Domain Trusted Cutoff718.35
Noise Cutoff523.55
Domain Noise Cutoff523.55
Isology Typeequivalog
HMM Length1076
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination biological_process
AuthorHaft DH
Entry DateJan 9 2006 5:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentDNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RecAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. The partner may be designated AddB, as in Bacillus and in alphaproteobacteria, or RexB as in Streptococcus and Lactococcus. Note, however, that RexB proteins lack an N-terminal GxxGxGK[ST] ATP-binding motif found in Bacillus subtilis and related species, and this difference may be important; this model represents specifically RexB proteins as found in Streptococcus and Lactococcus.
Genome PropertyGenProp0493: addAB pathway (HMM)