HMM Summary Page: TIGR02773

Functionhelicase-exonuclease AddAB, AddB subunit
Gene SymboladdB
Trusted Cutoff903.70
Domain Trusted Cutoff903.70
Noise Cutoff453.50
Domain Noise Cutoff453.50
Isology Typeequivalog
EC Number3.1.-.-
HMM Length1159
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination biological_process
GO:0004003: ATP-dependent DNA helicase activity molecular_function
AuthorHaft DH
Entry DateJan 9 2006 5:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentDNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function.
Genome PropertyGenProp0493: addAB pathway (HMM)