HMM Summary Page: TIGR02772

FunctionKu protein
Trusted Cutoff204.30
Domain Trusted Cutoff204.30
Noise Cutoff89.95
Domain Noise Cutoff89.95
Isology Typeequivalog
HMM Length259
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006303: double-strand break repair via nonhomologous end joining biological_process
GO:0045027: DNA end binding molecular_function
AuthorHaft DH
Entry DateJan 9 2006 9:41AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are Ku proteins of non-homologous end joining (NHEJ) DNA repair in bacteria and in at least one member of the archaea (Archaeoglobus fulgidus). Most members are encoded by a gene adjacent to the gene for the DNA ligase that completes the repair. The NHEJ system is broadly but rather sparsely distributed, being present in about one fifth of the first 250 completed prokarytotic genomes. A few species (e.g. Archaeoglobus fulgidus and Bradyrhizobium japonicum) have multiple copies that appear to represent recent paralogous family expansion.
ReferencesDR PFAM; PF02735; Ku70/Ku80 beta-barrel domain
Genome PropertyGenProp0492: nonhomologous end-joining, bacterial type (HMM)