HMM Summary Page: TIGR02765

Functioncryptochrome, DASH family
Trusted Cutoff317.05
Domain Trusted Cutoff317.05
Noise Cutoff267.50
Domain Noise Cutoff267.50
Isology Typesubfamily
HMM Length431
Mainrole CategoryCellular processes
Subrole CategoryAdaptations to atypical conditions
AuthorHaft DH
Entry DateJan 4 2006 4:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentPhotolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes.
ReferencesRN [1] RM 15147276 RT Identification of cryptochrome DASH from vertebrates. RA Daiyasu H, Ishikawa T, Kuma K, Iwai S, Todo T, Toh H. RL Genes Cells. 2004 May;9(5):479-95. RN [2] RT Purification and characterization of three members of the photolyase/cryptochrome family glue-light photoreceptors from Vibrio cholerae. RA Worthington EN, Kavakli IH, Berrocal-Tito G, Bondo BE, Sancar A. RL J Biol Chem. 2003 Oct 3;278(40):39143-54. RN [3] RM 10871367 RT Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803. RA Hitomi K, Okamoto K, Daiyasu H, Miyashita H, Iwai S, Toh H, Ishiura M, Todo T. RL Nucleic Acids Res. 2000 Jun 15;28(12):2353-62.