HMM Summary Page: TIGR02760

Functionconjugative transfer relaxase protein TraI
Gene SymboltraI
Trusted Cutoff929.85
Domain Trusted Cutoff929.85
Noise Cutoff664.40
Domain Noise Cutoff664.40
Isology Typeequivalog
EC Number3.6.4.12
HMM Length1960
AuthorSelengut J
Entry DateDec 29 2005 8:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is a component of the relaxosome complex. In the process of conjugative plasmid transfer the realaxosome binds to the plasmid at the oriT (origin of transfer) site. The relaxase protein TraI mediates the single-strand nicking and ATP-dependent unwinding (relaxation, helicase activity) of the plasmid molecule. These two activities reside in separate domains of the protein [1].
ReferencesRN [1] RM PMID: 15629940 RA Matson SW, Ragonese H. RT The F-plasmid TraI protein contains three functional domains required for conjugative DNA strand transfer. RL J Bacteriol. 2005 Jan;187(2):697-706.
Genome PropertyGenProp0484: F-type conjugation system (type IV secretion) specific components (HMM)