HMM Summary Page: TIGR02752

Functiondemethylmenaquinone methyltransferase
Gene SymbolmenG
Trusted Cutoff419.85
Domain Trusted Cutoff419.85
Noise Cutoff409.30
Domain Noise Cutoff409.30
Isology Typeequivalog
EC Number2.1.1.163
HMM Length231
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0008168: methyltransferase activity molecular_function
GO:0009234: menaquinone biosynthetic process biological_process
AuthorHaft DH
Entry DateDec 21 2005 3:54PM
Last ModifiedDec 12 2011 10:34PM
CommentMenG is a generic term for a methyltransferase that catalyzes the last step in menaquinone biosynthesis; the exact enzymatic activity differs for different MenG because the menaquinone differ in their prenoid side chains in different species. Members of this MenG protein family are 2-heptaprenyl-1,4-naphthoquinone methyltransferase, and are found together in operons with the two subunits of the heptaprenyl diphosphate synthase in Bacillus subtilis and related species.
ReferencesRM 9139683 RT Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus. RA Koike-Takeshita A, Koyama T, Ogura K. RL J Biol Chem. 1997 May 9;272(19):12380-3. DR HAMAP; MF_01813; 19 of 275