HMM Summary Page: TIGR02751

Functionphosphoenolpyruvate carboxylase
Gene SymbolppcA
Trusted Cutoff146.05
Domain Trusted Cutoff146.05
Noise Cutoff145.20
Domain Noise Cutoff145.20
Isology Typeequivalog
EC Number4.1.1.31
HMM Length506
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0008964: phosphoenolpyruvate carboxylase activity molecular_function
AuthorHaft DH
Entry DateDec 21 2005 2:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family is the archaeal-type phosphoenolpyruvate carboxylase, although not every host species is archaeal. These sequences bear little resemblance to the bacterial/eukaryotic type. The members from Sulfolobus solfataricus and Methanothermobacter thermautotrophicus were verified experimentally, while the activity is known to be present in a number of other archaea.
ReferencesRN [1] RM 15516590 RT Identification and functional verification of archaeal-type phosphoenolpyruvate carboxylase, a missing link in archaeal central carbohydrate metabolism. RA Ettema TJ, Makarova KS, Jellema GL, Gierman HJ, Koonin EV, Huynen MA, de Vos WM, van der Oost J. RL J Bacteriol. 2004 Nov;186(22):7754-62. RN [2] RM 15262949 RT The phosphoenolpyruvate carboxylase from Methanothermobacter thermautotrophicus has a novel structure. RA Patel HM, Kraszewski JL, Mukhopadhyay B. RL J Bacteriol. 2004 Aug;186(15):5129-37. DR HAMAP; MF_01904; 27 of 27