HMM Summary Page: TIGR02729

FunctionObg family GTPase CgtA
Gene SymbolcgtA
Trusted Cutoff280.25
Domain Trusted Cutoff280.25
Noise Cutoff111.00
Domain Noise Cutoff111.00
Isology Typeequivalog
HMM Length329
Mainrole CategoryProtein synthesis
Subrole CategoryOther
Gene Ontology TermGO:0005525: GTP binding molecular_function
GO:0042254: ribosome biogenesis biological_process
AuthorHaft DH
Entry DateDec 9 2005 4:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal.
ReferencesDR PFAM; PF01018; GTP1_OBG RN [1] RM 15836769 RT The GTP binding protein Obg homolog ObgE is involved in ribosome maturation. RA Sato A, Kobayashi G, Hayashi H, Yoshida H, Wada A, Maeda M, Hiraga S, Takeyasu K, Wada C. RL Genes Cells. 2005 May;10(5):393-408. RN [2] RM 15554976 RT The Caulobacter crescentus GTPase CgtAC is required for progression through the cell cycle and for maintaining 50S ribosomal subunit levels. RA Datta K, Skidmore JM, Pu K, Maddock JR. RL Mol Microbiol. 2004 Dec;54(5):1379-92. RN [3] RM PMID:17360576 RT Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae. RA Raskin DM, Judson N, Mekalanos JJ RL Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4636-41. RN [4] RM PMID:16980477 RT The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly. RA Jiang M, Datta K, Walker A, Strahler J, Bagamasbad P, Andrews PC, Maddock JR RL J Bacteriol. 2006 Oct;188(19):6757-70.
Genome PropertyGenProp0802: ribosome biogenesis proteins, bacteria (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)