HMM Summary Page: TIGR02723

Functionphenylphosphate carboxylase, alpha subunit
Gene SymbolppcA
Trusted Cutoff564.60
Domain Trusted Cutoff564.60
Noise Cutoff244.30
Domain Noise Cutoff244.30
Isology Typeequivalog
EC Number4.1.1.-
HMM Length485
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
AuthorHaft DH
Entry DateDec 7 2005 11:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the alpha subunit of phenylphosphate carboxylase. Phenol (methyl-benzene) is converted to phenylphosphate, then para-carboxylated by this four-subunit enzyme, with the release of phosphate, to 4-hydroxybenzoate. The enzyme contains neither biotin nor thiamin pyrophosphate. This alpha subunit is homologous to the beta subunit and, more broadly, to UbiD family decarboxylases.
ReferencesRM 15231788 RT Phenylphosphate carboxylase: a new C-C lyase involved in anaerobic phenol metabolism in Thauera aromatica. RA Schuhle K, Fuchs G. RL J Bacteriol. 2004 Jul;186(14):4556-67.