HMM Summary Page: TIGR02721

Functionthiamine kinase
Gene SymbolthiK
Trusted Cutoff299.45
Domain Trusted Cutoff299.45
Noise Cutoff98.95
Domain Noise Cutoff98.95
Isology Typeequivalog
EC Number2.7.1.89
HMM Length256
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0009228: thiamine biosynthetic process biological_process
GO:0019165: thiamine kinase activity molecular_function
AuthorHaft DH
Entry DateDec 6 2005 3:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the ycfN gene product of Escherichia coli, now identified as the salvage enzyme thiamine kinase (thiK), and additional proteobacterial homologs taken to be orthologs with equivalent function.
ReferencesRN [1] RM 15150256 RT Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. RA Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP. RL J Bacteriol. 2004 Jun;186(11):3660-2. DR HAMAP; MF_01604; 18 of 19