HMM Summary Page: TIGR02718

Functionsiderophore transporter, RhtX/FptX family
Trusted Cutoff356.15
Domain Trusted Cutoff356.15
Noise Cutoff217.80
Domain Noise Cutoff217.80
Isology Typesubfamily
HMM Length390
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0015891: siderophore transport biological_process
GO:0042927: siderophore transporter activity molecular_function
AuthorHaft DH
Entry DateDec 2 2005 10:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentRhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see PF07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes.
ReferencesDR PFAM; PF07690; MFS_1; transporter, major facilitator family RM 15126460 RT Identification of rhtX and fptX, novel genes encoding proteins that show homology and function in the utilization of the siderophores rhizobactin 1021 by Sinorhizobium meliloti and pyochelin by Pseudomonas aeruginosa, respectively. RA Cuiv PO, Clarke P, Lynch D, O'Connell M. RL J Bacteriol. 2004 May;186(10):2996-3005.