HMM Summary Page: TIGR02717

Functionacetyl coenzyme A synthetase (ADP forming), alpha domain
Gene Symbolacs
Trusted Cutoff567.15
Domain Trusted Cutoff567.15
Noise Cutoff463.00
Domain Noise Cutoff463.00
Isology Typeequivalog_domain
EC Number6.2.1.13
HMM Length447
Gene Ontology TermGO:0003985: acetyl-CoA C-acetyltransferase activity molecular_function
GO:0046356: acetyl-CoA catabolic process biological_process
AuthorSelengut J
Entry DateDec 2 2005 3:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlthough technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized [1,2,3]. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference [1], one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.
ReferencesRN [1] RM 8830684 RT Purification and characterization of two reversible and ADP-dependent acetyl coenzyme A synthetases from the hyperthermophilic archaeon Pyrococcus furiosus. RA Mai X, Adams MW RL J Bacteriol. 1996 Oct;178(20):5897-903 RN [2] RM 10375639 RT Cloning and sequencing of an acetyl-CoA synthetase (ADP-forming) gene from the amitochondriate protist, Giardia lamblia. RA Sanchez LB, Morrison HG, Sogin ML, Muller M RL Gene. 1999 Jun 11;233(1-2):225-31 RN [3] RM 11069669 RT Early lateral transfer of genes encoding malic enzyme, acetyl-CoA synthetase and alcohol dehydrogenases from anaerobic prokaryotes to Entamoeba histolytica. RA Field J, Rosenthal B, Samuelson J RL Mol Microbiol. 2000 Nov;38(3):446-55